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One 12-week randomized clinical trial found that subjects receiving 1mg daily lost an average of 2.6kg compared to 0.8kg in the placebo group

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Growth hormone-induced insulin resistance in human subjects involves reduced pyruvate dehydrogenase activity

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Liver/Kidney/CYP450: High-dose systemic copper chelate therapy requires strict monitoring of ceruloplasmin and unbound serum copper to prevent heavy metal toxicity or Wilson-like hepatic accumulation